JOINT ACTIVE with UC-II®

Key indications 主要适用范围:

· Knee pain & stiffness 膝盖疼痛和僵硬

· Joint pain & inflammation 关节疼痛及炎症

· Arthritis – Osteo & Rheumatoid

关节炎 - 骨关节炎与类风湿性关节炎

· Cartilage and joint damage, prevention and repair from sports, wear & tear and ageing

预防由运动，磨耗损伤和老化造成的软骨和关节损伤和帮助修复

· Athletes such as runners 运动员 - 赛跑选手

· Bone health support 维护骨骼健康

Key selling points 主要卖点:

Key features 主要特点

· Triple action support

三重作用，三重维护

· Small, 1-a-night capsule

体积小，每晚一粒胶囊

· Contains UC-II® a patented Type II undenatured collagen

含有UC-II® - 专利的II型未变性胶原蛋白

Supported by clinical research in healthy, active adults, including research at Harvard Medical School 临床研究用健康活跃的成年人证实功效，其中包括哈佛医学院的研究

· Contains no shellfish/seafood

不含贝类/海鲜

Key benefits 关键功效

· 1. Preserves joints 保护关节

· 2. Regenerates cartilage 软骨再生

· 3. Supports healthy bones 维护骨骼健康

· Small capsule = greater compliance

胶囊体积小=能更容易遵医嘱

· Ideal for people who can’t swallow big tablets

适用于无法吞咽大颗药片的人士

· 1 small capsule = 2 large Glucosamine & Chondroitin capsules

1粒小胶囊=2大颗氨基葡萄糖和软骨素胶囊

· Take on its own or take with existing joint products if preferred

可单独服用或与现有关节维护产品配套服用

· Works 2.5-times faster than Glucosamine & Chondroitin & shown to be more effective in overall pain relief 比氨基葡萄糖和软骨素胶囊效能快2.5倍，缓解疼痛的效果更优越

Works with the immune system to deactivate the cells that attack joint tissue allowing the body to reduce inflammation and repair cartilage 与免疫系统合作，抑止攻击关节组织细胞的活性，让身体减少炎症，修复软骨细胞

Demonstrates 40mg once a day is significantly better than glucosamine & chondroitin in people with osteoarthritis研究显示在骨关节炎患者身上，每日一次40毫克的剂量显着的比氨基葡萄糖和软骨素胶囊有效

· Reduce pain and inflammation

减轻疼痛和炎症

· Stop cartilage and bone erosion

停止软骨和骨质腐损

· Repair and re-build cartilage

修复和重新建造软骨

· Improve mobility & flexibility

改善可动性和灵活性

· Promote long term joint health

增进关节的长期健康

· Non-allergenic

无过敏性反应

Dosage 剂量: Take 1 capsule daily.  For best results, take with water on an empty stomach just before bedtime. 每日1粒。若欲发挥最佳效果，请在睡前空腹配白开水服用。

Osteoarthritis (OA) is characterized by an inflammatory synovial response that leads to joint wear and tear and can be attributed to age, weight, acidity, injury, biomechanics etc. 骨关节炎（OA）的特征是滑膜发炎导致关节磨损，可以归因于年龄、体重、体内酸碱值、损伤、骨力学等。

Rheumatoid arthritis (RA) is an autoimmune disease in which the body’s own immune system turns against itself and killer T-cells begin to attack the joint cartilage resulting in inflammation and joint destruction.

Many of the biochemical markers associated with OA inflammation are also associated with RA inflammation. UC-II suppresses the T-cell mediated inflammation in both forms of arthritis.

类风湿关节炎（RA）是一种自身免疫性疾病，人体自身免疫系统变为对自身攻击，Ｔ淋巴细胞开始攻击关节软骨，导致炎症和关节损毁。许多有关骨关节炎的生化标志物也与类风湿性关节炎相关联。 UC-II可抑制T细胞介导的这两种形式关节炎。

Ingredients 成分: (per capsule 每粒含量)

UC-II®  Standardised Cartilage 40mg

Providing Bioactive Undenatured Type II Collagen 1.2mg

含有UC-II® 具有生物活性的II型未变性胶原蛋白

Boron (from Borax) 硼（硼砂） 2mg

Vitamin D3  (Cholecalciferol 5mcg) 维生素D3（胆钙化醇5微克） 200IU

Key ingredients 主要成分:

UC-II® - Undenatured Type II collagen (Type II = joint health Type I & III = skin health)

Type II Collagen is the primary structural component in cartilage.  Unlike other collagen or joints products, UC-II collagen deactivates collagen-specific T-cells (i.e cells that attack collagen), allowing the body to reduce inflammation and rebuild and repair articular cartilage. Only a small daily dose is needed.  Small amounts have been shown to be the most effective.

UC-II® - 未变性II型胶原蛋白（II型=关节健康，I型和III型=皮肤健康）

II型胶原蛋白是软骨的主要结构成分。不像其他的胶原蛋白或关节保健产品，UC-II型胶原蛋白去除胶原特异性T细胞（即攻击胶原蛋白的细胞）的活性，减轻炎症，让身体重建和修复关节软骨，每日只需要一颗小的剂量。低剂量已被证明是最有效的。

Undenatured Type II collagen means that it is not processed by heat (uses a low temp) or chemicals (stays in its native state). This ensures the biological activity remains active.  If it is heated then it loses its immune modulating ability and also its ability to rebuild and repair the joints.

未变性II型胶原蛋白意指它不是经由高温或化学制品加工，而是用低温让其停留在原本的天然状态。这确保了它的生物活性。如果被加热，就会失去其调节免疫的能力，和重建和修复关节的能力。

Mechanism of action 作用机制:

1. Initiation 启动: Ageing, stress, injury leads to wear and tear of joint cartilage resulting in initiation of inflammatory responses (pro-inflammatory cytokines). 老化，压力，损伤造成关节软骨磨损，从而导致发炎反应（促炎细胞因子）

2. T-cell activation T细胞活化: Once inflammation reaches a threshold – the body’s defense system responds by releasing collagen specific T-cells which activate the production collagen specific antibodies from B-cells which in turn migrate and bind to collagen. 一旦炎症达到临限值 - 人体的防御系统透过释放胶原蛋白特异性T细胞，其会激活B细胞中的胶原蛋白特异性抗体的生成，之后迁移并与胶原蛋白结合。

3. De-activation 失活作用: – UC-II works by deactivating collagen specific T-cells, halting and even reversing the progression of Osteoarthritis allowing joints the opportunity to heal and regenerate.

UC-II contains special molecules called Epitopes. These are immune system markers that interact with certain antibodies to trigger the de-activation of collagen-specific T-cells and in turn help deactivate the inflammatory process.

UC-II使胶原特异性T细胞失活，可停止或甚至逆转骨关节炎，让关节有机会愈合和再生。

UC-II含有特殊的分子，称为抗原表位。这些是免疫系统的标志物，与特定的抗体相互作用以触发特定胶原T细胞的失活进而帮助停止炎症。

Vitamin D3 - Vitamin D is required for the optimal function and production of Cartilage as well as helping to promote strong healthy bones. Boron – is essential for healthy bones and is shown to be deficient in people with Osteoarthritis & Rheumatoid arthritis. Joints receive nutrients through adjoining bones – so healthy bones are key for healthy joints. 维生素D3 - 软骨要达到最佳功能和生产，以及促进强健的健康骨骼都需要维生素D。 硼 - 对健康的骨骼至关重要，被证明在骨关节炎和类风湿性关节炎患者中缺乏。通过相邻的骨头接收营养素 - 所以拥有健康关节的关键就是先有健康的骨骼。